The growth of a tumor, just like the growth of a cell or an organism, requires nutrients and a means to convert nutrients into the basic building blocks that support life. These metabolic processes are frequently deregulated in cancer cells to facilitate growth and enable survival. Costas’ research as a member of the Cantley lab uses a multi-disciplinary approach encompassing methods in chemistry and biology to define how metabolism is rewired in cancer and then to employ this understanding in the design of targeted tumor metabolism-based therapies.