PUBLICATIONS

Hu XV, Lyssiotis CA, Tao H, Baker RK, Rodrigues TMA, Miraglia L, Orth AP, Lyons GE, Wu X & Schultz PG. (2010) A Functional Genomics Screen Identifies a Regulator of DNA Methylation.Submitted.

Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tuu B, Miraglia L, Walker J, Sun F, Orth A, Harris J, Schultz PG & Wu X. (2009) A Genomic Screen Identifies TYRO3 as a MITF Regulator and Melanoma Oncogene. Proc. Natl. Acad. Sci. 106. 17025-17030.§ Abstract | PDF | Supporting information

             § Highlighted in Scripps News & Views, October (2009). Scientists Make
             Advance Against Melanoma. Article

Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW & Glick GD. (2009) Bz-423 Superoxide Signals B Cell Apoptosis via Mcl-1, Bak, and Bax. Biochemical
Pharmacology. 78. 966-973. Abstract | PDF

Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez L, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG & Jaenisch R. (2009) Reprogramming of Murine Fibroblasts to iPS Cells With Chemical Complementation of Klf4. Proc. Natl. Acad. Sci. 106. 8912-8917.§ Abstract | PDF | Supporting information

§ PNAS 50-most read articles, June (2009). Article
§ Highlighted in Nature Cell Biology 11, 796 (2009). Chemical iPS Cocktails. Article | PDF
§ Highlighted in Nature Reports Stem Cells, May (2009). New Types of Embryonic Stem Cells Generated by Stabilizing Pluripotency. Article
§ Highlighted in Regenerative Medicine 4, 371-374 (2009). Article | PDF
§ Highlighted in Assay and Drug Development Technologies, August (2009). Discovering Pluripotent Compounds. PDF

Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X & Schultz PG. (2009) A Small Molecule Primes Embryonic Stem Cells for Differentiation by Targeting NME2. Cell Stem Cell. 4, 416–426.§ Abstract | PDF | Supporting information

§ Highlighted in Nature Chemical Biology 5, 456-457 (2009). Endowing Endoderm. Article | PDF
§ Highlighted in Cell Stem Cell 4, 373-374 (2009). Using Small Molecules to Great Effect in Stem Cell Differentiation. PDF
§ Highlighted in Molecular Interventions 9, 167 (2009). Stauprimide: A Small Molecule Directs Stem Cells to Differentiate. PDF

Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW & Glick GD. (2008) Bz-423 Superoxide Signals Apoptosis via Selective Activation of JNK, Bak, and Bax. Free Radical Biology Med. 45 (9), 1232-42. Abstract | PDF

Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG & Wu X. (2007) Inhibition of Histone Deacetylase Activity Induces Developmental Plasticity in Oligodendrocyte Precursor Cells. Proc. Natl. Acad. Sci. 104, 14982-14987.§ Abstract | PDF | Supporting information

§ Highlighted in Cell 131, 197-198 (2007). Leading Edge: Glial Precursors Break Their Commitment. PDF

Bednarski JJ, Lyssiotis CA, Roush RR, Boitano AE, Glick GD & Opipari AW. (2004) A novel benzodiazepine increases the sensitivity of B Cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis.  J. Biol. Chem. 279, 29615 – 29621. Abstract | PDF

REVIEWS and COMMENTARIES

Lyssiotis CA, Lairson LL, Boitano AE & Schultz PG (2010) Pharmacological Control of Stem Cell Fate and Developmental Potential: A Comprehensive Review. Angew. Chem. Int. Ed. Manuscript in Preparation, invited review.

Lyssiotis CA, Charette BD & Lairson LL. (2009) Reprogramming Developmental Potential. Lakshmipathy U, Chesnut JD & Thyagarajan B, eds. In: Emerging Technology Platforms for Stem Cells. New York, NY. John Wiley & Sons Press, Inc.; 51-85. Summary | PDF

Lyssiotis CA. (2007) Cautiously Interpret Data. Chemical & Engineering News. Nov. 12, 6. Article